Renal involvement is the most important prognostic factor in Henoch-Schoenlein purpura. There are few reports adult Henoch-Schoenlein nephritis compared with children's cases.
We retrospeictively analyzed the clinical and pathologic data of 32 patients with biopsy-proven Henoch-Schoenlein nephritis examined at Seoul National University Hospital. And the results were as follows.
1) 75% patients were younger than 30 and the male to female ratio was 20 : 12.
2) Abdominal pain was observed in 28(88%), Gast4rointestinal bleeding in 8(25%) and arthralgia in 19(59%). Of these, 7 patients had all triads.
3) Ther clinical syndrome at prescntation was asymptomatic urinary abnormality in 16, chronic glomerulonephritis in 7, nephrotic syndrome in 5 and acute glomerulonephritis in 4 patients.
4) Serum IgA level was elevated in 14%505). Serum complment level was all normal.
5) The pathologic diagnosis according to ISKDC classificantion was grade III in 24(75%), grade II in 5(16%), grade IV in 2(6%) grade V in 1(3%).
6) According to Meadow's classification, out of 21 patients who were followed up more than 6 months, 5 were classified as stage A, 7 as stage B, 5 as stage C and 4 as stage D.
These findings suggest that nephrotic syndrome at presentation, high pathologic grade and initial azotemia are poor prognostic factors.
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